%0 Journal Article %J Scand J Immunol %D 2012 %T Protective effect of HLA-DRB1 11 and predisposition of HLA-C 04 in the development of severe liver damage in Brazilian patients with chronic hepatitis C virus infection. %A Marangon, A V %A Silva, G F %A de Moraes, C F V %A Grotto, R M T %A Pardini, M I M C %A de Pauli, D S %A Visentainer, J E L %A Sell, A M %A Moliterno, R A %K Adult %K Alleles %K Brazil %K Female %K Gene Frequency %K Genetic Predisposition to Disease %K Haplotypes %K Hepatitis C, Chronic %K HLA-C Antigens %K HLA-DRB1 Chains %K Humans %K Immunophenotyping %K Liver %K Liver Cirrhosis %K Male %K Middle Aged %K Severity of Illness Index %K Time Factors %X

The objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty-five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1) typing were carried out by PCR-SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1 11 (5.0% versus 18.2%, P=0.0016, OR=0.23, CI 95% = 0.09-0.58; Pc=0.0208) and DRB1 11-DQA1 05-DQB1 03 haplotype (4.2% versus 15.3%, P=0.0032; OR = 0.24, CI 95% = 0.08-0.64). Liver damage was associated with HLA-C 04 in patients with <20 years of infection (38.4% versus 9.1%, P = 0.002, OR = 6.25, CI 95%=1.97-19.7; Pc=0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type-1 chronically infected Brazilian patients.

%B Scand J Immunol %V 76 %P 440-7 %8 10/2012 %G eng %N 4 %1

http://www.ncbi.nlm.nih.gov/pubmed/22803655?dopt=Abstract

%R 10.1111/j.1365-3083.2012.02755.x