Astrocytic complexity distinguishes the human brain.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Oberheim, Nancy Ann; Wang, Xiaohai; Goldman, Steven; Nedergaard, Maiken
Year of Publication: 2006
Journal: Trends Neurosci
Volume: 29
Issue: 10
Pagination: 547-53
Date Published: 2006 Oct
Publication Language: eng
ISSN: 0166-2236
Keywords: Adult, Animals, Astrocytes, Biological Evolution, Brain, Humans

One of the most distinguishing features of the adult human brain is the complexity and diversity of its cortical astrocytes. Human protoplasmic astrocytes manifest a threefold larger diameter and have tenfold more primary processes than those of rodents. In all mammals, protoplasmic astrocytes are organized into spatially non-overlapping domains that encompass both neurons and vasculature. Yet unique to humans and primates are additional populations of layer 1 interlaminar astrocytes that extend long (millimeter) fibers, and layer 5-6 polarized astrocytes that also project distinctive long processes. We propose that human cortical evolution has been accompanied by increasing complexity in the form and function of astrocytes, which reflects an expansion of their functional roles in synaptic modulation and cortical circuitry.

DOI: 10.1016/j.tins.2006.08.004
Alternate Journal: Trends Neurosci.
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