Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Yu, Fuli; Hill, R Sean; Schaffner, Stephen F; Sabeti, Pardis C; Wang, Eric T; Mignault, Andre A; Ferland, Russell J; Moyzis, Robert K; Walsh, Christopher A; Reich, David
Year of Publication: 2007
Journal: Science
Volume: 316
Issue: 5823
Pagination: 370
Date Published: 2007 Apr 20
Publication Language: eng
ISSN: 1095-9203
Keywords: Adaptation, Biological, African Continental Ancestry Group, Asian Continental Ancestry Group, Biological Evolution, Brain, European Continental Ancestry Group, Gene Frequency, Haplotypes, Humans, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Recombination, Genetic, Selection, Genetic, Sequence Analysis, DNA, Time

Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1720) suggested that ASPM, a gene associated with microcephaly, underwent natural selection within the last 500 to 14,100 years. Their analyses based on comparison with computer simulations indicated that ASPM had an unusual pattern of variation. However, when we compare ASPM empirically to a large number of other loci, its variation is not unusual and does not support selection.

DOI: 10.1126/science.1137568
Alternate Journal: Science