Comparative genetics of MHC polymorphisms in different primate species: duplications and deletions.

Bibliographic Collection:

MOCA Reference, APE

Publication Type: Journal Article

Authors: Bontrop, Ronald E

Year of Publication: 2006

Journal: Hum Immunol

Volume: 67

Issue: 6

Pagination: 388-97

Date Published: 2006 Jun

Publication Language: eng

ISSN: 0198-8859

Keywords: Animals, Evolution, Molecular, Gene Deletion, Gene Duplication, Genes, MHC Class I, Genes, MHC Class II, HLA-A Antigens, HLA-B Antigens, HLA-C Antigens, Humans, Major Histocompatibility Complex, Polymorphism, Genetic, Primates, Species Specificity

Abstract:

Gene products of the major histocompatibility complex (MHC) play a crucial role in the activation of adaptive (antigen-dependent) immune responses. In this paper similarities and dissimilarities among the MHCs of different primate species and their functional implications are reviewed. The human HLA system represents the most thoroughly investigated MHC of any contemporary living primate species, and so it will serve as a reference.

DOI: 10.1016/j.humimm.2006.03.007

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/16728259?dopt=Abstract

Alternate Journal: Hum. Immunol.

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