Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels.

Bibliographic Collection: 
APE, MOCA Reference
Publication Type: Journal Article
Authors: Britten, Roy J
Year of Publication: 2002
Journal: Proc Natl Acad Sci U S A
Volume: 99
Issue: 21
Pagination: 13633-5
Date Published: 2002 Oct 15
Publication Language: eng
ISSN: 0027-8424
Keywords: Animals, Chromosomes, Artificial, Bacterial, DNA, DNA Transposable Elements, Evolution, Molecular, Gene Rearrangement, Humans, Pan troglodytes, Sequence Alignment, Sequence Deletion, Sequence Homology, Nucleic Acid, Species Specificity

Five chimpanzee bacterial artificial chromosome (BAC) sequences (described in GenBank) have been compared with the best matching regions of the human genome sequence to assay the amount and kind of DNA divergence. The conclusion is the old saw that we share 98.5% of our DNA sequence with chimpanzee is probably in error. For this sample, a better estimate would be that 95% of the base pairs are exactly shared between chimpanzee and human DNA. In this sample of 779 kb, the divergence due to base substitution is 1.4%, and there is an additional 3.4% difference due to the presence of indels. The gaps in alignment are present in about equal amounts in the chimp and human sequences. They occur equally in repeated and nonrepeated sequences, as detected by REPEATMASKER.

DOI: 10.1073/pnas.172510699
Alternate Journal: Proc. Natl. Acad. Sci. U.S.A.