Evidence for superior parietal impairment in Williams syndrome

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Eckert, M. A.; Hu, D.; Eliez, S.; Bellugi, U.; Galaburda, A.; Korenberg, J.; Mills, D.; Reiss, A. L.
Year of Publication: 2005
Journal: Neurology
Volume: 64
Edition: 2005/01/12
Number: 1
Pagination: 152-3
Date Published: Jan 11
Type of Article: Research Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.
Publication Language: eng
ISBN Number: 1526-632X (Electronic)00
Accession Number: 15642924
Keywords: Adult, Female, Humans, Magnetic Resonance Imaging/methods, Parietal Lobe/*pathology, Williams Syndrome/*pathology

Parietal lobe impairment is hypothesized to contribute to the dramatic visual-spatial deficits in Williams syndrome (WS). The authors examined the superior and inferior parietal lobule in 17 patients with WS and 17 control female adults (CNLs). The right and left superior parietal lobule gray matter volumes were significantly smaller in patients with WS than in CNLs, even after controlling for total cerebral gray matter. Impaired superior parietal function could explain WS visual-spatial and visual-motor problems.


Neurology. 2005 Jan 11;64(1):152-3.

Alternate Journal: Neurology
Author Address:

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA. meckert@stanford.edu