A fine-scale map of recombination rates and hotspots across the human genome.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Myers, Simon; Bottolo, Leonardo; Freeman, Colin; McVean, Gil; Donnelly, Peter
Year of Publication: 2005
Journal: Science
Volume: 310
Issue: 5746
Pagination: 321-4
Date Published: 10/2005
Publication Language: eng
ISSN: 1095-9203
Keywords: Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Evolution, Molecular, Female, Genome, Human, Humans, Male, Models, Genetic, Polymorphism, Single Nucleotide, Recombination, Genetic
Abstract:

Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.

DOI: 10.1126/science.1117196
Alternate Journal: Science
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