Initial sequence of the chimpanzee genome and comparison with the human genome

Bibliographic Collection: 
CARTA-Inspired Publication, APE
Publication Type: Journal Article
Authors: The Chimpanzee Sequencing and Analysis Consortium
Year of Publication: 2005
Journal: Nature
Volume: 437
Edition: 2005/09/02
Number: 7055
Pagination: 69-87
Date Published: Sep 1
Type of Article: Comparative StudyResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.
Publication Language: eng
ISBN Number: 1476-4687 (Electronic)00
Accession Number: 16136131 PMID
Keywords: *Evolution, *Genome, *Genomics, Alleles, Alu Elements/genetics, Animals, Base Composition, Computational Biology, Disease, DNA Transposable Elements/genetics, Human, Humans, Molecular, Mutagenesis/genetics, Pan troglodytes/*genetics, Phylogeny, Polymorphi

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution.


EnglandNature. 2005 Sep 1;437(7055):69-87.

Alternate Journal: Nature