Microsatellite evolution--evidence for directionality and variation in rate between species.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Rubinsztein, D C; Amos, W; Leggo, J; Goodburn, S; Jain, S; Li, S H; Margolis, R L; Ross, C A; Ferguson-Smith, M A
Year of Publication: 1995
Journal: Nat Genet
Volume: 10
Issue: 3
Pagination: 337-43
Date Published: 1995 Jul
Publication Language: eng
ISSN: 1061-4036
Keywords: Alleles, Animals, Base Sequence, Biological Evolution, DNA Primers, DNA, Satellite, Genetic Markers, Humans, Models, Genetic, Molecular Sequence Data, Mutation, Pan troglodytes, Polymerase Chain Reaction, Primates, Repetitive Sequences, Nucleic Acid, Selection, Genetic, Species Specificity

Microsatellite DNA sequences are rapidly becoming the dominant source of nuclear genetic markers for a wide range of applications, from genome mapping to forensic testing to population studies. If misinterpretation is to be avoided, it is vital that we understand fully the way in which microsatellite sequences evolve. We have therefore compared allele length distributions for 42 microsatellites in humans with their homologues in a range of related primates. We find a highly significant trend for the loci to be longer in humans, showing that microsatellites can evolve directionally and at different rates in closely related species.

DOI: 10.1038/ng0795-337
Alternate Journal: Nat. Genet.
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