Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Kim, Bernard Y; Lohmueller, Kirk E
Year of Publication: 2015
Journal: Am J Hum Genet
Volume: 96
Issue: 3
Pagination: 454-61
Date Published: 2015 Mar 5
Publication Language: eng
ISSN: 1537-6605
Keywords: Alleles, Animals, Asian Continental Ancestry Group, European Continental Ancestry Group, Genetics, Population, Genome, Humans, Neanderthals, Population Density

It has been hypothesized that the greater proportion of Neandertal ancestry in East Asians than in Europeans is due to the fact that purifying selection is less effective at removing weakly deleterious Neandertal alleles from East Asian populations. Using simulations of a broad range of models of selection and demography, we have shown that this hypothesis cannot account for the higher proportion of Neandertal ancestry in East Asians than in Europeans. Instead, more complex demographic scenarios, most likely involving multiple pulses of Neandertal admixture, are required to explain the data.

DOI: 10.1016/j.ajhg.2014.12.029
Alternate Journal: Am. J. Hum. Genet.
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