Structural Identification of the Nicotinic Receptor Ion Channel.
Bibliographic Collection:
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Changeux, JP
Year of Publication: 2018
Journal: Trends Neurosci
Volume: 41
Number: 2
Pagination: 67-70
Date Published: Feb
Publication Language: eng
Accession Number: 29405928
Abstract:
The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are "framed" by anionic rings.
Author Address:
CNRS UMR 3571, Institut Pasteur, Paris F-75724 Cedex 15, France; Chaire de Communications Cellulaires, Collège de France, Paris F-75005, France. Electronic address: changeux@noos.fr.
Export:
