CCL3L1 (chemokine (C-C motif) ligand 3-like 1)

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Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
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CCL3L1, or Chemokine (C-C motif) ligand 3-like 1, has copy number variation in human populations, and this variation is known to affect resistance to HIV, causative virus for AIDS.  Because AIDS was introduced to modern human very recently (within 200 years), initial function of CCL3L1 is obviously not for HIV resistance.

The Human Difference: 

Copy number variation (CNV) between 1-6 copies exists.

Genetics Topic Attributes


  1. CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users., Huik, Kristi, Sadam Maarja, Karki Tõnis, Avi Radko, Krispin Tõnu, Paap Piret, Rüütel Kristi, Uusküla Anneli, Talu Ave, Abel-Ollo Katri, et al. , J Infect Dis, 2010 Mar, Volume 201, Issue 5, p.730-9, (2010)
  2. CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals, Ahuja, Sunil K., Kulkarni Hemant, Catano Gabriel, Agan Brian K., Camargo Jose F., He Weijing, O'Connell Robert J., Marconi Vincent C., Delmar Judith, Eron Joseph, et al. , Nature medicine, 04/2008, Volume 14, Issue 4, p.413-20, (2008)