CDH12 (cadherin 12, type 2 (N-cadherin 2) )
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Cadherin 12 is an integral membrane protein that mediates calcium-dependent cell-cell adhesion specifically in the brain. Changes in CDH12 have been associated with schizophrenia and violent suicide victims. Array comparative genomic hybridization indicates that CDH12 is present in the human genome in higher copy number than any other primate. Implications for this change in copy number are unknown.
Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR., , Genomics, 2010 Apr, Volume 95, Issue 4, p.203-9, (2010)
Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept., , Br J Psychiatry, 2009 Jul, Volume 195, Issue 1, p.23-9, (2009)
Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims., , Int J Neuropsychopharmacol, 2008 Mar, Volume 11, Issue 2, p.217-28, (2008)
Lineage-specific gene duplication and loss in human and great ape evolution., , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)