FRMPD2 (FERM and PDZ domain containing 2) | Center for Academic Research and Training in Anthropogeny (CARTA)

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MOCA Topic Authors:

Majesta O'Bleness

James Sikela

FERM and PDZ domain containing 2 (FRMPD2) is a peripheral membrane protein and is involved in polarizing and formation of tight cell-cell junctions in epithelial cells. FRMPD2 has approximately 2 more copies in the human genome than in other primates. The significance of these other copies is not understood.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
the emergence of the genus Homo was 2,000 thousand (2 million) years ago
the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
the common ancestor of modern humans was 100 - 300 thousand years ago

Probable Appearance:

2,000 thousand years ago

Definite Appearance:

6,000 thousand years ago

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol	Type of Human-Specific Changes
FRMPD2	Copy Number Changes

References

Diversity of human copy number variation and multicopy genes., Sudmant, Peter H., Kitzman Jacob O., Antonacci Francesca, Alkan Can, Malig Maika, Tsalenko Anya, Sampas Nick, Bruhn Laurakay, Shendure Jay, and Eichler Evan E. , Science, 10/2010, Volume 330, Issue 6004, p.641-6, (2010)
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PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells., Stenzel, N., Fetzer C.P., Heumann R., and Erdmann K. S. , J Cell Sci, 09/2009, Volume 122, Issue Pt 18, p.3374-84, (2009)
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