GRIN3A (Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A)
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Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A (GRIN3A) is a subunit of NMDA receptors, which are glutamate regulated ion-channels that regulate excitatory synaptic transmission. GRIN3A may be involved in the development of synaptic elements and genetic variation has been linked to Alzheimer’s disease. GRIN3A has an amino acid change that lead to a loss of a myristoylation site. This change has been hypothesized to have affected human learning and memory.
Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease., , Dement Geriatr Cogn Disord, Volume 28, Issue 6, p.521-7, (2009)
The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family., , BMC Evol Biol, Volume 9, p.224, (2009)