Kruppel-type Zinc Finger Family

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Human Uniqueness Compared to "Great Apes": 
Likely Difference

Zinc finger proteins are a family of transcription factors that regulate gene expression, and most of these proteins are members of the KZNF family. There are 7 human-specific novel KZNFs and 10 KZNFs that have undergone pseudogenization specifically in the human lineage. 30 additional KZNFs have experienced human-specific sequence changes that are presumed to be of functional significance. Members of the KZNF family are often in regions of segmental duplications, and multiple KZNFs have undergone human-specific duplications and inversions.

The Human Difference: 

Copy number change
Gene deletion
Novel genes

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  1. Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between species., Nowick, Katja, Fields Christopher, Gernat Tim, Caetano-Anolles Derek, Kholina Nadezda, and Stubbs Lisa , PLoS One, Volume 6, Issue 6, p.e21553, (2011)