MOXD2P (monooxygenase, DBH-like 2, pseudogene )
Certainty Style Key
True Likely Speculative
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Human Uniqueness Compared to "Great Apes":
Monooxygenase, DBH-Like 2 (MOXD2) is a membrane associated monooxygenase that is expressed in the medial olphactory epithelium and is highly conserved in mammals. MOXD2 in human contains a deletion that removed the last two exons from the gene which resulted in its pseugenization in the human lineage. A polymorphic nonsense mutation also exists in the 6th exon of some humans. Loss of MOXD2 has been hypothesized to have altered smell sensitivity in humans.
Inactivation of MOXD2 and S100A15A by exon deletion during human evolution., , Mol Biol Evol, 10/2007, Volume 24, Issue 10, p.2203-12, (2007)