NBPF15 (neuroblastoma breakpoint family, member 15)
Certainty styling is being phased out topic by topic.Hover over keys for definitions:
NBPF15 (Neuroblastoma breakpoint factor, member 15), originally called MGC8902, is a gene that was identified as having undergone a human lineage specific copy number increase via cDNA arrayCGH. This gene contains 6 predicted DUF1220 protein domains (domain of unknown function 1220), a domain that increases in copy number generally as a function of a species' evolutionary proximity to humans. DUF1220 is expressed in several human tissues including brain where its expression is restricted to neurons. It is highly expressed in brain regions associated with higher cognitive function, has been linked to 1q21.1 CNVs associated with microcephaly and macrocephaly, and has been hypothesized to play a key role in the evolution of the human brain.
DUF1220 domains, cognitive disease, and human brain evolution., , Cold Spring Harb Symp Quant Biol, 2009, Volume 74, p.375-82, (2009)
Human lineage-specific amplification, selection, and neuronal expression of DUF1220 domains., , Science, 2006 Sep 1, Volume 313, Issue 5791, p.1304-7, (2006)
Lineage-specific gene duplication and loss in human and great ape evolution., , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)