Association of HLA DRB1 alleles with juvenile idiopathic arthritis in Mexicans.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Silva-Ramirez, B; Cerda-Flores, R M; Rubio-Pérez, N; Vargas-Alarcón, G; Pérez-Hérnández, N; Granados-Arriola, J; Burgos-Vargas, R
Year of Publication: 2010
Journal: Clin Exp Rheumatol
Volume: 28
Issue: 1
Pagination: 124-7
Date Published: 01/2010
Publication Language: eng
ISSN: 0392-856X
Keywords: Adolescent, Alleles, Arthritis, Juvenile, Child, Child, Preschool, Female, Genetic Predisposition to Disease, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Incidence, Indians, North American, Infant, Male, Mexico, Prevalence

OBJECTIVE: The aim of the study was to investigate association between HLA class II alleles and juvenile idiopathic arthritis (JIA) in Mexican patients.

PATIENTS AND METHODS: We typed 120 patients with JIA and 99 healthy controls for HLA class II alleles were performed by PCR-SSO. Differences between the whole group of JIA and its subtypes and controls were calculated by using the Xi2; p-values were corrected (pc) with Bonferroni's test.

RESULTS: The alleles HLA-DRB1*01 (pc= 0.00083) and HLA-DRB1*04 (pc=0.0049) were strongly associated with systemic JIA, while HLA-DRB1*11 and HLA-DRB1*14 were found to have decreased frequencies in the patients with systemic JIA compared to the controls. Two alleles were found to have increased frequencies with JIA oligoarthritis subgroup, HLA-DRB1*11 (p=0.01, pc=NS) and HLA-DRB1*13 (p=0.01, pc=NS). The HLA-DRB1*04 was found increased frequencies with susceptibility for RF negative and RF positive polyarthritis JIA subgroups (p correction resulted in loss of significance). In contrast two alleles HLA-DRB1*07 and HLA-DRB1*14 were found decreased frequencies only patients RF positive polyarthritis JIA subgroup compared to the controls (pc=NS).

CONCLUSION: The profile of HLA-DRB1 alleles associations in Mexican with JIA were somewhat distinct from association typically found in Caucasians.

Alternate Journal: Clin. Exp. Rheumatol.