HLA-DRB1* allele-associated genetic susceptibility and protection against multiple sclerosis in Brazilian patients.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Kaimen-Maciel, Damacio R; Reiche, Edna Maria V; Borelli, Sueli D; Morimoto, Helena K; Melo, Fabiano C; Lopes, Josiane; Dorigon, Raffael F; Cavalet, Christiane; Yamaguchi, Elton M; Silveira, Thiago L; Da Silva, Waldir V; Comini-Frota, Elizabeth R; Brum Souza, Doralina G; Donadi, Eduardo A
Year of Publication: 2009
Journal: Mol Med Rep
Volume: 2
Issue: 6
Pagination: 993-8
Date Published: 11/2009
Publication Language: eng
ISSN: 1791-3004

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system that causes neurological disorders in young adults. Previous studies in various populations highlighted an association between the HLA-DRB1*15 allele and MS. This study investigated the association between HLA-DRB1*15 and other HLA-DRB1 alleles and MS in a Brazilian Caucasian population sample from Londrina, Southern Brazil. HLA-DRB1 alleles were analyzed by polymerase chain reaction with specific sequence oligonucleotide primers in 119 MS patients and in 305 healthy blood donors as a control. Among the MS patients, 89 (75.0%) presented with relapsing remitting MS, 24 (20.0%) with secondary progressive MS and 6 (5.0%) with primary progressive MS. The frequency of the HLA-DRB1*15 allele observed in the MS Brazilian patients was similar to findings reported in previous studies carried out in populations worldwide. However, the results showed a higher frequency of the HLA-DRB1*15 allele in the MS patients compared to the controls, with a relative frequency of 0.1050 (10.50%) and 0.0443 (4.4%), respectively (OR=2.53; 95% CI 1.43-4.46; p=0.0009). A protector allele was also detected. The frequency of the HLA-DRB1*11 allele was reduced in the MS patients compared to the controls, with a relative frequency of 0.1345 (13.4%) and 0.1869 (18.7%), respectively (OR=0.67; 95% CI 0.44-1.03; p=0.0692). The results demonstrated that the HLA-DRB1*15 allele in heterozygosity is positively associated with MS (p=0.0079), and may be considered a genetic marker of susceptibility to the disease. A negative association between the HLA-DRB1*11 allele in homozygosity and MS was also verified (p=0.0418); this allele may be considered a genetic marker of resistance to MS in the Brazilian population.

DOI: 10.3892/mmr_00000204
Alternate Journal: Mol Med Rep