Protective effect of HLA-DRB1 11 and predisposition of HLA-C 04 in the development of severe liver damage in Brazilian patients with chronic hepatitis C virus infection.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Marangon, A V; Silva, G F; de Moraes, C F V; Grotto, R M T; Pardini, M I M C; de Pauli, D S; Visentainer, J E L; Sell, A M; Moliterno, R A
Year of Publication: 2012
Journal: Scand J Immunol
Volume: 76
Issue: 4
Pagination: 440-7
Date Published: 10/2012
Publication Language: eng
ISSN: 1365-3083
Keywords: Adult, Alleles, Brazil, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Hepatitis C, Chronic, HLA-C Antigens, HLA-DRB1 Chains, Humans, Immunophenotyping, Liver, Liver Cirrhosis, Male, Middle Aged, Severity of Illness Index, Time Factors
Abstract:

The objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty-five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1) typing were carried out by PCR-SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1 11 (5.0% versus 18.2%, P=0.0016, OR=0.23, CI 95% = 0.09-0.58; Pc=0.0208) and DRB1 11-DQA1 05-DQB1 03 haplotype (4.2% versus 15.3%, P=0.0032; OR = 0.24, CI 95% = 0.08-0.64). Liver damage was associated with HLA-C 04 in patients with <20 years of infection (38.4% versus 9.1%, P = 0.002, OR = 6.25, CI 95%=1.97-19.7; Pc=0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type-1 chronically infected Brazilian patients.

DOI: 10.1111/j.1365-3083.2012.02755.x
Alternate Journal: Scand. J. Immunol.