A genetic change that decreases an individual’s fitness and increases susceptibility to or causes disease or disorder. Most deleterious mutations are recessive, i.e. selection can only act on them when an individual carries two copies of the same mutation.
Study of population size over time.
A tropical disease caused by the Dengue virus and spread several species of female Aedes mosquitos, especially A. aegypti. Symptoms may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Severe infections may develop into Dengue Hemorrhagic Fever or Dengue Shock Syndrome.
|Aedes Mosquitos, Dengue Hemorrhagic Fever, Dengue Shock Syndrome, Dengue Virus, Infection|
|Dengue Hemorrhagic Fever||
A severe form of Dengue Fever, which includes bleeding and blood platelet and blood plasma leakage.
|Dengue Shock Syndrome||
A severe form of Dengue Fever in which dangerously low blood pressure occurs.
The cause of Dengue Fever. It is a mosquito- borne, single positive-stranded RNA virus of the genus, Flavivirus. Origin: Africa and Asia.
|Dengue Fever, Genus, RNA virus|
An extinct hominin population contemporary with Neanderthals that hybridized with ancient humans and Neanderthals. Knowledge of Denisovan morphology is limited to two small fossils found in Siberia and a jaw in Tibet.
Calcified dental plaque, provides information on diet, disease, health, microbiome and protects the genetic information within the tooth from degradation.
|Deoxyribonucleic acid (DNA)||
The molecule of inheritance, which consists of sequences of the four nucleotide bases: Adenine, Thymine, Guanine, and Cytosine.
|Molecule, Nucleotide, Sequence|
Variants arising since last common ancestor.
An irreversible biological characteristic acquired during growth and development in a stressful environment.
A selective disorder characterized by marked impairment in episodic memory despite relatively preserved semantic memory.
Spreading effects over time across systems or domains of function that result from interactions in dynamic systems and cumulatively alter development.
Psychosocial milestones or accomplishments expected of people of different ages in a given cultural and historical context; Common developmental tasks include bonding with caregivers, walking, talking, learning to read, getting along with other people, and caring for one’s children.
|Diffusor Tensor Imaging (DTI)||
Neuroimaging of the location, orientation, and anisotropy of the brain’s white matter tracts through MRI.
|Functional Magnetic Resonance Imaging (fMRI), White Matter (Brain)|
The organs of the body that are involved in the breakdown and absorption of food, and elimination of wastes. This includes the mouth, pharynx (throat), esophagus, stomach, small intestine, large intestine, rectum, and accessory digestive organs such as the salivary glands, liver, gallbladder, and pancreas.
Organisms with two sets of each chromosome except for XY sex chromosomes in male mammals.
Outwardly apparent effects of a disease.
The ability to refer to entities, properties, and events at some spatial and/or temporal remove from the immediate communicative situation (Kluender, 2020).
Change in genetic content or phenotype between isolated populations or species.
Northern Chad. A fossil rich desert that is most famous for the discovery of Sahelenthropous tchadensis (Toumai) in 2001.
A process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription.
|Deoxyribonucleic acid (DNA), Gene, Molecule, Sequence, Transcription|
The specific order of the nucleotide bases along a strand of DNA.
|Deoxyribonucleic acid (DNA), Nucleotide|
The process of artificial selection by humans for desired traits of plants, animals, fungi, and microorganisms. This implies the complete control of the reproduction of those species.
A neurotransmitter that is involved in reward circuits, motor control, and in the release of various hormones.
|Dose or Risk Gradient||
A graph showing a pattern of rising problems or undesirable outcomes as the level of trauma, exposure to disaster, or number of cumulative risk factors or ACEs increases.
A gene that encodes the dopamine receptor D2 protein, a receptor targeted by many antipsychotic drugs.
A chronically relapsing disorder characterized by loss of control and compulsive drug seeking.
A theory that human behavior is a product of two different and interacting evolutionary processes: genetic evolution and cultural evolution. Genes and culture continually interact in a feedback loop.
|Duality of Patterning||
The ability to combine and recombine meaningless linguistic elements (sounds in spoken language, or manual features like handshape, palm orientation, movement, etc. in signed language) into meaningful units (words or signs) (Kluender, 2020).
A class of endogenous opioid peptides that have been shown to play a role in the complex molecular changes in the brain that result from cocaine addiction.
A general term for disorders that involve difficulty in learning to read or interpreting words, letters, and other symbols, but that do not affect general intelligence.
A state of unease or general dissatisfaction.
|Early-night wake therapy (EWT)||
A sleep schedule therapy hypothesized to relieve peripartum depression by altering melatonin and sleep timing (sleep from 3:00 - 7:00 am).
|Earth Microbiome Program (EMP)||
A crowd-sourced effort to characterize microbial life on Earth founded by Jack Gilbert (UC San Diego), Janet Jansson (PNNL), and Rob Knight (UC San Diego).
|Eastern Equine Encephalitis (EEE)||
A rare but serious and often fatal infection of Togavirus that causes encephalitis (inflammation of the brain). The virus is maintained via a bird- to-mosquito cycle, primarily by mosquitos that feed on the blood of birds. Transmission of EEE to mammals (including horses and humans) occurs via “bridge vectors,” mosquito (including those from the Aedes genus) that feed on the blood of both birds and mammals and transfer the virus. Origin: Americas.
|Aedes Mosquitos, Genus, Togavirus (Togaviridae), Virus|
|Eccrine sweat gland||
A type of secretory gland found in the skin. These glands are found throughout the body of humans and other primates. In response to neural stimulation, these glands secret water (sweat) onto the skin. In humans, eccrine sweat glands are the most abundant glands in the skin and are essential for the main mechanism of cooling in our species, which occurs when water (sweat) secreted by these glands causes evaporative cooling.
The interaction of organisms with their physical environment, along with other organisms.
The outermost of the three primary germ layers formed in embryonic development and develops into the nervous system and skin.
A class of organs that all develop from the outer layer of the embryo, the ectoderm, through a series of coordinated and reciprocal interactions between the embryonic ectoderm and underlying dermal layer. This class of organs includes, sweat glands, hairs, mammary glands, teeth and nails. A largely shared set of genetic pathways initiate and control the development of this organ class.
|Effective Population Size (Ne)||
The size of an idealized population (random mating, no selection, mutation or migration) with the same rate of genetic drift as the study population.
The relationship between the work performed to move a certain distance to the energy cost of transport.
Large herbivorous mammals recognized by their long trunks, tusks, large ear flaps, and pillar-like legs. Elephants are found throughout sub-Saharan Africa, South Asia, and Southeast Asia and consist of three species, the Africa bush elephant (Loxodonta africana), the African forest elephant (L. cyclotis), and the Asian elephant (Elephas maximus).
The use of individualized machine learning applied to functional MRI data to measure diverse mental states during meditation.
The development of an embryo after fertilization of an egg cell.
|Embryonic stem cell (ESC)||
The inner cell mass of the human blastocyst, the rapidly dividing fertilized egg at four to seven days post fertilization. ESCs are pluripotent, meaning they can differentiate into all cell types of the three embryonic tissue layers.
The gradual acquisition of cultural traits (the characteristics and norms of a culture or group) by an individual or another culture.
A species that is very likely to become extinct in the near future, either locally or worldwide.
In epidemiology, an infection that is constantly maintained at a baseline level in a population in a geographic area without external inputs.
|Endocrine disrupting chemicals (EDCs)||
Substances that interfere with the normal function of the endocrine system. These can be present in the environment (air, soil, or water supply), food sources, personal care products, and manufactured products.
A hormonal system comprising internal glands, such as the hypothalamus, pituitary, thyroid, and adrenal, that produce, store, and release hormones into the circulatory system to regulate the body’s healthy development and function.
The innermost of the three primary germ layers formed in embryonic development and develops into some of the body’s internal organs, including the gastrointestinal tract, the urinary tract, the respiratory tract, endocrine glands, and the auditory system.
|Endothelia PAS Domain Protein 1 (EPAS1) gene||
A protein encoding gene for EPAS1. This gene is implicated in high altitude adaptation in humans, specifically in Tibetan populations that admixed with Denisovan archaic hominins and inherited this advantageous gene variant.
|Denisovans, Gene, Protein|
|Endothelia PAS Domain Protein 1 (EPAS1) protein||
A transcription factor involved in the response to changes in oxygen concentration, such as hypoxia, through the induction of oxygen regulated genes.
The cell type that forms the interior lining of blood and lymphatic vessels, and controls the transfer of materials, including white blood cells, into and out of the bloodstream.
|Lymphatic vessels, White blood cells (WBCs)|
Short region of DNA that can be bound by proteins to alter transcription of a gene.
Viruses that possess an outer lipid membrane formed by cell membrane of the host cells from which the virus buds. The envelope protects the virus as it travels between hosts and cells.
Proteins that catalyze chemical reactions inside and outside cells.
The rapid spread of a disease to a significant percent of a given population.
The branch of medicine that studies and analyzes the incidence, distribution, patterns, determinants, and possible control of diseases and other health factors.
Biological information not encoded directly in DNA.
|Deoxyribonucleic acid (DNA)|
A term first coined by the developmental biologist, Conrad Waddington, in 1942 to explain how a singular genotype might produce variations in phenotype across development. He argued that some level of regulation must exists “above” or “over” genes to determine when and where they are expressed. Today the term refers to stable alterations in gene expression without changes to the underlying DNA sequence.
|Deoxyribonucleic acid (DNA), Epigenetic, Epigenome|
Molecular modifications of the DNA and its associated histone proteins, affecting its function.
The cell type that lines the surfaces of the body, including skin, mucus membranes (airways, gastrointestinal tract, reproductive tract), urinary tract, and organs to provide protection.
|Erythrocytes (red blood cells - RBCs)||
The most common type of blood cell and the vertebrate’s principal means of oxygen delivery from lungs or gills to all tissues of the body. Erythrocytes of most mammals do not contain a nucleus with chromosomes.
An estrogen steroid hormone and the major female sex hormone that is involved in the regulation of reproductive cycles, the development of female secondary sexual characteristics, the development and maintenance of female reproductive tissues, and has important effects on bone, fat, skin, liver, and the brain. Estradiol also has important roles in males, but is produced in much lower levels.
|Estrogen, Hormone, Sex hormone, Steroid|
The category of sex hormones that includes estrone, estradiol, and estriol that are involved in the development and regulation of the female reproductive system and secondary sex characteristics.
|Estradiol, Sex hormone|
An intravenous agent used for general anesthesia and sedation for short procedures that suppresses corticosteroid synthesis.
|Corticosteroids, General anesthesia|
Open chromatin, allowing information to be read.
Organisms whose cells have a nucleus enclosed within membranes.
The most common type of melanin found in human skin and hair. There are two types, brown eumelanin and black eumelanin, which are involved in pigmentation. Deficiency causes albinism.
Excess nutrient accumulation in bodies of water that cause phytoplankton.
The application of modern evolutionary theory to understanding health and disease.
The study of the evolution and natural history of nervous system structure, functions, and emergent properties.
A theoretical approach to psychology that seeks evolutionary connections to human psychological traits such as cognition and language.
A chemical messenger that increases the likelihood that the neuron will fire an electrical signal (depolarization of the membrane) called an action potential.
Sequences at a locus that encode parts of a protein.
|Introns, Locus (pl. loci), Protein|
A type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them. They are taken up by distant cells, where they can affect cell function and behavior.
|Deoxyribonucleic acid (DNA), Protein, Ribonucleic acid (RNA)|
A paired macrostructure in the brain that is involved in reward cognition.
The structural network of enzymes, glycoproteins, and collagen that support surrounding cells.
Human-specific (malignant) malaria caused by the protozoan parasite, Plasmodium falciparum.
Eastern Senegal. Excavations have led to the the discovery of paleolithic occupations from different periods, cultures, and lithic technologies.
The ability to recognize that others can have beliefs about the world that are diverging. An important component of Theory of Mind.
|Theory of Mind (ToM)|
A molecule composed of a long chain of lipid-carboxylic acid, which is either saturated (single bonds between the components of the fatty acid chain) or unsaturated (at least one double bond within the fatty acid chain).
|Female- vs. male -biased fertile sex ratios||
The relative numbers of individuals capable of having children. In female-biased situations, males face less competition for mating opportunities. In male-biased situations, these opportunities are lower, thus greater male-male competition for each one.
The relative likelihood that an allele will be represented in future generations (relative to other alleles in the same population). Compare with Reproductive Success.
Replaced all other alleles in a population.
Inanimate objects (clothes, furniture, door handles, etc.) that when contaminated can transfer disease.
The point in time when a foot (or hand in the forelimb) first touches the ground.
The distribution of footsteps, relative to one another; some gaits may be defined by footfall sequence.
Searching for wild food or provisions as opposed to cultivating food crops or breeding livestock.
The front limbs and feet of a quadrupedal animal (also, the upper limbs/arms of a human).
A digestive process in which plant materials are fermented in a specialized combination of stomach compartments together called the reticulorumen. In ruminants, the fermented cud of the reticulorumen is regurgitated and chewed again to further break down the plant material, a process called rumination. After rumination, the food is finally digested in other stomach compartments, the omasum and abomsum (true stomach). Foregut fermentation also exists in some species that do not ruminate, such as leaf monkeys.
A protein that is rapidly synthesized in neurons when they become active and therefore is used as a marker of neuron activity and is involved in regulating gene expression.
|FOXP2||A gene in humans that encodes for a transcription factor protein and is involved in the production of speech.|
|Fragmented Maternal Care||
A measure of abnormal mothering in rodents. Fragmentation score reflects disruptions in the temporal pattern of care typically displayed by rodents. High fragmentation scores indicate shorter nursing bouts and generally erratic behavior.
|Frontal lobe (brain)||
The largest of the four major lobes of the brain in mammals, and is located at the front of each hemisphere. It is devoted to action such as skeletal movement, ocular movement, speech control, the expression of emotions. In humans, the largest part of the frontal cortex is the prefrontal cortex.
|Pre-frontal cortex (brain)|
Human frontal and parietal lobes form a network that is crucially involved in the selection of sensory contents by attention.
Encodes biological information.
|Functional Magnetic Resonance Imaging (fMRI)||
A neuroimaging technique for measuring and mapping brain activity that is noninvasive and safe. The phenomenon of nuclear magnetic resonance (NMR) is used to generate a signal that can be mapped and turned into an image of brain activity.