An experimental paradigm in which the experimenter separates a mother rat or mouse from her offspring for some period of time (minutes to hours) to study the effects of maternal deprivation on offspring development.
The sex with the higher potential rate of reproduction invests more in mating effort than in parental effort. Greater mating effort is associated with faster life history strategy.
|Mechanistic Target of Rapamycin (mTOR)||
A protein kinase, which in humans is encoded by the MTOR gene.
|Medial Preoptic Area (MPOA)||
A region of the brain located in the anterior part of the hypothalamus that critically regulates care giving behavior.
|Medium Spiny Neurons||
A special type of GABAergic inhibitory cell representing 95% of neurons within the human striatum, a basal ganglia structure.
|Basal Ganglia (Brain)|
For most organisms, it is the pigment in skin and hair, but is also found in the iris of the eye, the inner ear, and some parts of the brain. Melanin is produced as three basic types: eumelanin, pheomelanin, and neuromelanin. The melanin in the skin is produced by melanocytes, which exist across human populations in similar concentration in their skin. However, the melanocytes in some populations produce variable amounts of melanin. This variation is likely due to the melanin’s property to absorb and dissipate UV radiation, protecting skin from harmful damage. UV exposure is associated with increased risk of malignant melanoma, a cancer of melanocytes.
The faculty by which the mind stores and remembers information.
An inflammation (swelling) of the protective membranes covering the brain and spinal cord.
|Meningococcus (Neisseria meningitidis)||
A bacterium that can cause meningitis and meningococcemia, a life-threatening infection in the bloodstream (sepsis).
The time of life when female menstruation naturally and permanently ceases.
The process of representing and reasoning about the mental states, thought, and feelings of the self and others. Also known as Theory of Mind.
|Theory of Mind (ToM)|
A potent psychedelic found in the peyote cactus. Structurally similar to dopamine and norepinephrine and also activates serotonin receptors.
|Dopamine, Norepinephrine (noradrenaline), Peyote (Lophophora williamsii), Receptor|
The middle of the three primary germ layers formed in embryonic development and develops into the muscles of the cardiac and skeletal systems, the skeleton and connective tissue, blood vessels and cells, and some other internal organs such as the kidneys and gonads.
The rate at which fuels (such as sugars or fats) are broken down for the production of cellular energy.
The conversion of food into energy and the chemical building blocks for proteins, lipids, nucleic acids, and glycans as well as the elimination of metabolic wastes.
|Glycans, Lipid, Nucleic acid, Protein|
The process of using systems biology to understand microbes and their environment.
The totality of all organisms (microbes) that live on and in the body.
Microorganisms, such as bacteria, archaea, protists, fungi, and viruses, that are found in a particular environment.
A type of glia that functions as the primary innate immune cells of the central nervous system and are involved in brain development and maintenance. These cells are not of neuronal origin but rather migrate from the yolk sac to the brain during embryogenesis.
|Central nervous system (CNS), Embryogenesis, Glia (neuroglia)|
|Microlithic (Mode 5)||
A stone tool type consisting of small blades or points, called microliths, that were typically used in composite tools, such as an arrow point fastened to a haft. ~35 - 3 kya.
A chemical element or substance required in trace amounts for the normal growth and development of living organisms that the organism cannot synthesize itself.
A single-stranded non-coding RNA that silences RNA and is involved in post-transcriptional regulation of gene expression.
|Ribonucleic acid (RNA)|
|Middle East respiratory syndrome (MERS)||
A contagious and sometimes fatal viral respiratory sickness that can produce severe symptoms such as fever, cough, shortness of breath and in some cases death. The MERS virus originated in bats and was first reported affecting other species, camels and humans, in Saudi Arabia in 2012. Since then, it has been identified in many other countries, including the United States.
|Contagious (disease), Respiratory, Virus|
The second subdivision of the Paleolithic, or Stone Age and consist of use of prepared cores (Levallois Technique) and hafted tools and weapons. ~300 kya -30 kya.
A period of geological time (781-126,000 years ago). An important time for the diversification of hominins, including the emergence of Neanderthals and Homo sapiens.
The element of an individual that enables them to be aware of the world and their experiences, to think, and to feel; the faculty of consciousness and thought.
|Mind Over Reality Transition (MORT)||
A proposed singular phase in hominid evolution in which maladaptive mortality salience and death anxiety were triggered by acquiring the capacity for Extended Theory of Mind, but were (in this one instance) tolerated by the simultaneous acquisition of Reality Denial in the same minds - allowing gene culture-evolution to fix both capacities in the resulting hominin lineage, at the neurobiological and genetic level.
|Mortality Salience, Reality Denial, Theory of Mind (ToM)|
The state of being conscious or aware.
A meditative practice centered around being present in the moment.
Fossils or fossil fragments of bacteria, protists, fungi, animals, and plants (e.g.: starch granules) that can only be seen with a microscope.
Membrane-bound cell organelles that generate most of the chemical energy, adenosine triphosphate (ATP), needed to power the cell’s biochemical reactions. Mitochondria are believed to be endosymbionts that were originally prokaryotic cells that became incorporated into eukaryotic organisms.
Maternally inherited DNA found only in the mitochondria, the energy producing organelles of eukaryotic cells. Mitochondria are thought to descend from symbiotic bacteria that have become part of eukaryotic cells.
|Bacteria, Chromosome, Deoxyribonucleic acid (DNA), Eukaryotes|
The phenomenon whereby one organism produces molecules that are identical or very similar to those of another organism (such as its host). Parasites and pathogens repeatedly evolve molecular mimicry for host manipulation and immune evasion.
|Host, Parasite, Pathogen|
A group of two or more atoms covalently bonded together to form the smallest fundamental unit of a chemical compound that can take part in a chemical reaction.
A simple sugar; the most basic unit of a carbohydrate.
The rate of disease in a population (as opposed to mortality, which is death rate).
The shape or form (outward appearance) of an organism. The branch of biology interested in the form and structure of organisms and their specific structural features.
The sub-discipline of linguistics concerned with the structure and parts of words (stems, root words, prefixes, and suffixes), how words are formed, and their relationship to other words in the same language. Parts of speech, intonation and stress, and contextual pronunciation and meaning are aspects of Morphology.
Conscious understanding and realization of personal mortality.
The part of the cerebral cortex in the brain where the nerve impulses originate that initiate voluntary muscular activity.
A part of the nervous system that carries signals from the brain to skeletal muscle and smooth muscle.
The part of the nervous system that controls voluntary movement.
|Motor theory of vocal learning||
A theory that proposes the brain pathways that control the learning and production of song and speech were derived from adjacent motor brain pathways.
|Mousterian (Mode 3)||
A stone tool type characterized by hand- axes, scrapers, triangle points, and denticulates (a stone tool with edges of multiple notched shapes, or teeth) produced using a prepared core (i.e. Levallois Technique) and is most associated with Neanderthals. ~315 - 30 kya.
A slimy or gooey substance (hydrated bio-gel) produced by mucous membranes and glands for to lubricate or protect the body. The substance we refer to as “snot” or “boogers” are the mucus inside your nose that traps dirt and germs before they can enter further into your body and do you harm. Sneezing expels these invaders from your body but also propels them out towards other unsuspecting victims.
A group of genetic diseases that cause progressive weakness and loss of muscle mass.
An auditory form of art composed of pitch (melody and harmony), rhythm (tempo, meter, articulation), dynamics (loudness/softness), timbre and texture.
|Musicality (in humans)||
A natural, spontaneously developing sensitivity to, knowledge of, or talent for music based on and constrained by our biological and cognitive system, which is then culturally informed and reinforced.
Change in a DNA or RNA sequence.
|Deoxyribonucleic acid (DNA), Indel, Ribonucleic acid (RNA), Silent Mutations, Single Nucleotide Polymorphism (SNP), Synonymous/Non-synonymous Mutations|
Million years ago.
The pathogenic bacteria that causes tuberculosis.
An insulating layer of fatty tissue (wrapped cell membrane) that protects nerve cells, especially their axons.
|Axon (nerve fiber)|
|N-acetylneuraminic acid (Neu5Ac)||
The most common sialic acid in most vertebrates and was first discovered in animal saliva and brains.
|N-glycolylneuraminic acid (Neu5Gc)||
A common variant of sialic acid in many vertebrates that is not made by humans but can be incorporated from diets rich in red meat.
|Naked mole-rat (Heterocephalus glaber)||
A burrowing rodent endemic to parts of Ethiopia, Kenya, and Somalia, and is the only mammal with cold-blooded-like body temperature regulation and eusocial behavior.
|Natural Antibodies (NAb)||
A type of antibody that exists in the absence of active immunization via infection and/or contact with fetal antigens during pregnancy as a first line of defense until a specific antibody response is mounted.
An extinct Eurasian hominin species that existed from 500-30 kya and interbred with ancient humans and Denisovans.
|Denisovans, Hominin, Species|
A response or behavior that is strengthened by stopping, removing, or avoiding a negative outcome or aversive stimulus.
The failure to provide for the development of the child in all spheres: health, education, emotional development, nutrition, shelter, and safe living conditions (including protecting the child from harm). It is the most common form of child maltreatment. In rodents, neglect it is similarly defined as inconsistent care, failure to group displaced infants in the nest, infant avoidance and failure to protect infants from harm or potential harm.
A part of the cerebral cortex concerned with sight, hearing, and touch in mammals, regarded as the most recently evolved part of the cortex.
The new growth of cells proliferating without regard to stop signals and with attendant new blood vessels that forms a neoplasm.
A tumor mass, either benign (not cancer) or malignant (cancer), that is composed of cells that have lost their regulatory checks and multiply without control or do not undergo pre-programmed cell death.
The delay or slowing of development. Compared to other primates, humans are considered neotenous due to the retention of physiological traits typical of juveniles such as facial features (globular skull shape, thinness of skull bones, reduction of browridge, flattened face, larger eyes), limb length ratio, and behavior.
|Nerve||A bundle of fibers that transmits impulses of sensation to the brain or spinal cord, and impulses from these to the muscles and organs.|
The network of nerve cells and fibers that transmits nerve impulses between parts of the body.
A neural circuit is a functional entity of interconnected neurons that is able to regulate its own activity using a feedback loop.
|Neural progenitor cell (NPC)||
Cells that are capable of dividing a limited number of times and have the capacity to differentiate into a restricted repertoire of neuronal and glial cell types.
|Glia (neuroglia), Neuron|
|Neural stem cell (NSC)||
A self-renewing, multipotent cell that generates the neurons and glia of the nervous system of all animals during embryonic development. Some persist in the adult vertebrate brain and continue to produce neurons throughout life.
|Glia (neuroglia), Nervous system, Neuron|
The study of the morphology, behavior, and other qualities of the nervous system.
The process by which neural stem cells produce neurons.
|Neural stem cell (NSC)|
The study of the role of genetics in the development and function of the nervous system.
A branch of linguistics that examines the connection between language and the structure and functioning of the brain.
Relating to the anatomy, functions, and organic disorders of nerves and the nervous system.
A subset of neurotransmitters that regulate diverse populations of other neurons.
A specialized cell that transmits nerve impulses.
The ability of the brain to form and reorganize synaptic connections through growth and reorganization. These changes include new neural connections and cortical remapping resulting from learning, environmental influences, practice, and psychological stress.
The study of the relationship between behavior, emotion, and cognition and brain function.
A multidisciplinary science that is concerned with the study of the structure and function of the nervous system. It encompasses the evolution, development, cellular and molecular biology, physiology, anatomy and pharmacology of the nervous system, as well as computational, behavioral and cognitive neuroscience.
A type of chemical messenger that transmits signals across a chemical synapse, such as a neuromuscular junction, from one neuron (nerve cell) to another “target” neuron, muscle cell, or gland cell.
A chemical released by nerve cells to send signals to other cells.
A membrane receptor protein that is activated by a neurotransmitter.
Not displaying or characterized by autistic or other neurologically atypical patterns of thought or behavior.
A bundle of fibers that transmits impulses of sensation to the brain or spinal cord, and impulses from these to the muscles and organs.
A form of ecological inheritance in which organisms alter the environment in ways that affect the developmental context and selection pressures acting on subsequent generations.
A natural alkaloid and insecticide produced by several plant species (tobacco and jimson weed). It also functions as a central nervous system stimulant as an analog of the neurotransmitter acetylcholine.
|Central nervous system (CNS), Neurotransmitter|
|Nicotinic acetylcholine receptor||
A receptor polypeptide that responds to the neurotransmitter, acetylcholine, and also responds to nicotine.
A common chemical element with the atomic number 7. Most nitrogen on earth exists as inert gas (N2).
|Non-coding RNA (ncRNA)||
RNA that is not translated into a protein. Important ncRNAs include transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs), as well as small RNAs such as microRNAs, siRNAs, piRNAs, snoRNAs, snRNAs, exRNAs, scaRNAs and the long ncRNAs such as Xist and HOTAIR.
|microRNA (miRNA), Protein, Ribonucleic acid (RNA)|
|Non-Hormonal Basis of Maternal Care||
The finding that care giving behavior can occur in female rats and mice that have not reproduced themselves through repeated exposure to infants.
The use of various techniques, such as Functional Magnetic Resonance Imaging, to image the structure, function, or pharmacology of the nervous system.
|Functional Magnetic Resonance Imaging (fMRI)|
Depression that is not related to changes in the seasons.
So called “smart drugs” or cognitive enhancers that are claimed to improve cognitive function. E.g., Modafinil.
A hormone and neurotransmitter that mobilizes the brain and body for action.
A new strain of a disease that has not been previously identified in a species.
|de Novo, Species|
|Nuclear Pore Complex||Protein and ribonucleoprotein transport channels in the nuclear envelop of eukaryotic cells. Evolved ~ 1.5 billion years ago. While the primary role of NPCs is to regulate nucleo–cytoplasmic transport, recent research suggests that certain NPC proteins have additionally acquired the role of affecting gene expression at the nuclear periphery and in the nucleoplasm in metazoans.|
Atmospheric areas that generate particulate matter PM2.5 from dissolved ammonia from agricultural nitrogen pollution.
|Agricultural nitrogen pollution, PM2.5|
One of the four classes of major biomolecules. The overall name for DNA and RNA, which are composed of nucleotides. DNA is double-stranded and more stable while RNA is single-stranded and less stable.
|Deoxyribonucleic acid (DNA), Nucleotide, Ribonucleic acid (RNA)|
|Nucleoporin 98 (Nup98)||A protein coding gene that plays a role in the nuclear pore complex assembly and/or maintenance. Associated diseases range from Myelodysplastic Syndrome and Acute Monocytic Leukemia.||Nuclear Pore Complex|
Glycosylamines corresponding to nucleotides lacking a phosphate.
Molecular building blocks for DNA and RNA Specifically, they consist of three components: a 5-carbon sugar, a phosphate group, and a nitrogenous base. The type of sugar, either deoxyribose or ribose, determines if the resulting nucleic acid is DNA or RNA.
|Deoxyribonucleic acid (DNA), Nucleic acid, Ribonucleic acid (RNA)|