A lack of early childhood exposure to infectious agents, symbiotic microorganisms and parasites believed to increase susceptibility to allergies and autoimmune diseases.
Increased sensitivity to pain.
Pain, hypohedonia, dysphoria, anxiety, hyperalgesia, irritability, and sleep disturbances associated with drug abstinence following excessive drug taking.
|Dysphoria, Hyperalgesia, Hypohedonia|
A neuropeptide that regulates arousal, wakefulness, and appetite.
A diminished capacity for pleasure.
Less than the normal amount of oxygen reaching the tissues; also, low partial pressure of oxygen at high elevations (hypobaric hypoxia).
A sign that shares perceived physical properties with the thing it refers to (its “referent”) (Kluender, 2020).
A mode of behavior or way of thought peculiar to an individual.
|Immediate Return Hunter-Gatherers||
Those who do not store food, but consume it within a day or two of obtaining it. This means there is no opportunity to accumulate surplus.
Cells that are part of the immune system. Most develop from stem cells in the bone marrow and become different types of white blood cells (the microglia of the brain originate in the yolk sack during embryonic development). Immune cells are broadly classified into innate and adaptive immune cells. Innate immune cells include neutrophils, basophils, mast cells, monocytes and eosinophils, dendritic cells, and macrophages. Adaptive immune cells include B-cells and T-cells. T-Cells and Natural Killer T-cells mediate important dialogues between innate (rapid) and adaptive (slower) immune responses. B-cells and T-cells can form long- term immunological memory.
|B-cell (B lymphocyte), Immune System|
The biological defense system of an organism that protects against disease.
The capability of multicellular organisms to resist harmful microorganisms from entering it and compromising its biological systems. The balanced state of adequate biological defenses to fight infection, disease, or other unwanted biological invasion, while having adequate tolerance to avoid allergy, and autoimmune diseases. It critically relies on recognition of both self and non-self.
A class of glycoproteins present in the serum and on cells of the immune system. (see Antibody)
|Antibody, Glycoprotein, Immune System|
The branch of biology and biomedicine concerned with the study of immune systems.
Long non-coding microRNA
Insertions or deletions of DNA sequence.
A sign that depends for its reference on the physical presence of the thing that it refers (its “referent”) to at some point in space and time (e.g. smoke, a weather vane, a bullet hole, your index finger) (Kluender, 2020).
|Induced Pluripotent Stem Cells (iPSC)||
Somatic (body) cells that are artificially reprogrammed to an embryonic-like stem cell state and differentiated into other types of cells.
The invasion of an organism’s organs or tissues by pathogens, their multiplication, and the reaction of the host tissues to the pathogens.
The capability of producing infection or spreading disease to others. Synonymous with communicable and transmissible.
|Communicable (Disease), Infection, Transmissible (Disease)|
|Inferior Frontal Gyrus (Brain)||
The lowest positioned gyrus of the frontal gyri, of the frontal lobe, and is part of the prefrontal cortex. It is located in Broca’s area, which is involved in language processing and speech production.
|Broca’s Area (Brain), Frontal Lobe (Brain), Gyrus (Brain), Prefrontal Cortex (Brain)|
|Inferior Temporal Cortex (Brain)||
The cerebral cortex on the inferior convexity of the temporal lobe in primates, including humans and is It is crucial for visual object recognition.
|Cerebral Cortex (Brain)|
An often-painful localized redness, swelling, and heat that is the body’s response to an injury or infection. While uncomfortable, it indicates that your body is working hard to repair itself or to defend against infection.
Often referred to as “flu,” this is a highly contagious viral respiratory illness. Symptoms include fever, severe body aches, and catarrh. Because it is so contagious, influenza often produces epidemics. There are several influenza viruses that affect humans (A, B, C).
|Catarrh, Contagious (Disease), Epidemic, Respiratory|
A chemical messenger that decreases the likelihood that the neuron will fire an electrical signal called an action potential (see also excitatory neurotransmitter).
The power of minds to be about, to represent, or to stand for, things, properties and states of affairs. Refers to the ability of the mind to form representations and should not be confused with intention. Beliefs about others’ beliefs display what is sometimes known as “higher-order intentionality.”
The space between births.
|Intersectional neuroscience framework||
A research framework that adapts procedures to be more inclusive of underrepresented groups through community engagement with diverse participants and individualized methods to accommodate neural diversity.
|Intracellular Signaling Cascade||
The series of sequential events that transmit signals received at the surface of a neuron to internal regulatory molecules, which are then modified by the signal. These pathways allow external signals from the environment to regulate gene expression.
The interval of life between conception and birth.
Transfer of alleles between species.
Sequences between eons, don't encode proteins
|Exons, Locus (pl. Loci)|
A thing that one knows or considers likely from instinctive feeling rather than conscious reasoning.
A potent inhalational anesthetic used for induction and maintenance of general anesthesia. Works via GABA receptors.
Each of two or more forms of the same element that contain equal numbers of protons but different numbers of neutrons in their nuclei, and hence differ in relative atomic mass but not in chemical properties; in particular, a radioactive form of an element.
The ratio of non-radiogenic “stable isotopes,” stable radiogenic isotopes, or unstable radioactive isotopes of particular elements in an investigated material.
An infection of the central nervous system caused by the Japanese Encephalitis Virus. Most infections are benign but occasionally can cause inflammation of the brain (encephalitis), headaches, vomiting, fever, confusion and seizures.
|Inflammation, Japanese Encephalitis Virus (JEV), Nervous System|
|Japanese Encephalitis Virus (JEV)||
A RNA virus of the genus Flavivirus that causes Japanese Encephalitis and is generally spread by mosquitoes, such as Aedes mosquitos. JEV is prevalent in much of Asia and the Western Pacific. Pigs and wild birds serve as a reservoir for the virus.
|Aedes Mosquitos, Genus, Japanese Encephalitis, Reservoir (Medicine), RNA virus, Virus|
A yellowing of the eyes and skin due to rapid breakdown of red blood cells (RBCs) and release of degraded hemoglobin.
|Hemoglobin, Red Blood Cells (RBCs)|
|Jebel Irhoud Hominins||
The oldest known “early” human fossils discovered, dating to roughly 300 kya from an archaeological site in Morocco. The location of this discovery suggests a “pan-African” origin of humans, with a dispersed interbreeding population, likely aided by climactic factors.
|John Ssebunya of Uganda||
In 1989, at age 4-5, he witnessed his father murder his mother and subsequently fled into the Ugandan jungle. He was accepted as a peripheral member of a group of vervet monkeys who cared for and nourished him for a period of two years. He was found and captured in 1991.
Chromosome number in the cell nucleus.
A river and cave system in the Tsitsikamma coast, Humansdorp district, Eastern Cape Province, South Africa. Evidence for middle stone age-associated human habitation has been found in the nearby cave system dating to ~125 kya.
A palaeoanthropological area in the southern Main Ethiopian Rift that was discovered 1991 The Konso-Gardula sediments span ~ 1.9 mya to 1.3 mya. Early Homo fossils and Acheulean stone tools have been found here.
Thousand years ago.
A genus of Gram-positive, rod-shaped bacteria that convert sugars to lactic acid. In humans, they are a significant component of the microbiome and can survive in the harsh pH conditions of the digestive and genital systems. Lactobacillus species are normally a major part of the vaginal microbiota. While receiving nutrients from their human host, Lactobacilli protect the host against certain pathogens, even helping to treat diarrhea, vaginal infections, and skin disorders such as eczema. Lactobacillus is the most common probiotic, perhaps most notable for its use in yogurt.
|Bacteria, Genus, Gram-Negative and Gram-Positive Staining, Infection, Microbiome, Pathogen, Species, Vaginal Microbiome|
A common genus of beneficial Lactobacillus bacteria that produces hydrogen peroxide (H202) and is found in the vagina and gastrointestinal system.
A common genus of beneficial Lactobacillus bacteria that normally inhabits the lower reproductive system and vagina of healthy women.
A structured system of communication that is generative (combine words/symbols to convey an infinite number of ideas), recursive (builds upon itself without limit), and has displaced reference (describe things not present).
Individuals from high-risk backgrounds who begin to manifest resilience later in adolescence or adulthood following a period of maladjustment or problems.
|Late-night wake therapy (LWT)||
A sleep schedule therapy hypothesized to relieve peripartum depression by altering melatonin and sleep timing (sleep from 9:00 pm - 01:00 am).
|Levallois Technique (prepared core)||
A method of creating stone tools by first striking flakes off the stone, or core, along the edges to create the prepared core and then striking the prepared core in such a way that the intended tool is flaked off with all of its edges pre-sharpened.
The schedule of life, including birth to sexual maturity, duration of the reproductive period, duration of the post-reproductive period (if there is one), and mortality rate at each stage.
|Limbic System (Brain)||
Structures of the brain that deal with emotions and memory.
|Limited Bedding and Nesting||
A paradigm used in the laboratory to model scarcity of resources. Mothers (rats/mice) are not given enough nesting materials to build a nest for their infants and neglect/maltreatment occurs as a result.
Non-random inheritance of alleles at different loci (due to low recombination).
One of the four classes of major biomolecules. A fatty or waxy organic compound involved in important cellular activities like storing energy, as a component of the cell membrane, and signaling within and between other cells.
|Locus (pl. Loci)||
A unique physical position on a chromosome.
The oldest known stone tools consisting of 150 artifacts found in Lomekwi, Kenya, close to Lake Turkana. ~3.3 mya.
Typical length of life.
The first subdivision of the Paleolithic, or Stone Age. ~3.4 mya- 300 ky.
A substance required in relatively large amounts by living organisms: Fats, proteins, carbohydrates in an animal diet or chemical elements such as potassium, magnesium, calcium as required by plants.
|Maintenance and Defense||
An organism’s way of maintaining its body and physiological homeostasis while also defending against parasites, pathogens, and internal crises (e.g. cancer).
|Major depression (clinical depression)||
A severe and persistent low mood, profound sadness, or a sense of despair lasting at least two weeks but usually much longer.
A genotypic or phenotypic trait that is (or has become) more harmful than helpful in determining survival and reproductive success (in contrast to an adaptation, which is more helpful than harmful).
An infectious disease that affects humans and other animals and caused by single-celled organisms belonging to genus Plasmodium and transmitted by mosquitos (commonly female Anopheles mosquitos). Initial symptoms are flu-
|Anopheles Mosquitos, Genome, Hemoglobin, Infectious (Disease), Jaundice, Plasmodium, Sickle Cell Trait|
The soft fatty substance in the cavities of bones that produces red and white blood cells and platelets.
An experimental paradigm in which the experimenter separates a mother rat or mouse from her offspring for some period of time (minutes to hours) to study the effects of maternal deprivation on offspring development.
The sex with the higher potential rate of reproduction invests more in mating effort than in parental effort. Greater mating effort is associated with faster life history strategy.
|Mechanistic Target of Rapamycin (mTOR)||
A protein kinase, which in humans is encoded by the MTOR gene.
|Medial Preoptic Area (MPOA)||
A region of the brain located in the anterior part of the hypothalamus that critically regulates care giving behavior.
|Medium Spiny Neurons||
A special type of GABAergic inhibitory cell representing 95% of neurons within the human striatum, a basal ganglia structure.
|Basal Ganglia (Brain)|
For most organisms, it is the pigment in skin and hair, but is also found in the iris of the eye, the inner ear, and some parts of the brain. Melanin is produced as three basic types: eumelanin, pheomelanin, and neuromelanin. The melanin in the skin is produced by melanocytes, which exist across human populations in similar concentration in their skin. However, the melanocytes in some populations produce variable amounts of melanin. This variation is likely due to the melanin’s property to absorb and dissipate UV radiation, protecting skin from harmful damage. UV exposure is associated with increased risk of malignant melanoma, a cancer of melanocytes.
The faculty by which the mind stores and remembers information.
|Meningococcus (Neisseria meningitidis)||
A bacterium that can cause meningitis and meningococcemia, a life-threatening infection in the bloodstream (sepsis).
A potent psychedelic found in the peyote cactus. Structurally similar to dopamine and norepinephrine and also activates serotonin receptors.
|Dopamine, Norepinephrine (noradrenaline), Peyote (Lophophora williamsii), Receptor|
The totality of all organisms (microbes) that live on and in the body.
|Microlithic (Mode 5)||
A stone tool type consisting of small blades or points, called microliths, that were typically used in composite tools, such as an arrow point fastened to a haft. ~35 - 3 kya.
A chemical element or substance required in trace amounts for the normal growth and development of living organisms that the organism cannot synthesize itself.
|Middle East Respiratory Syndrome (MERS||
A contagious and sometimes fatal viral respiratory sickness that can produce severe symptoms such as fever, cough, shortness of breath and in some cases death. The MERS virus originated in bats and was first reported affecting other species, camels and humans, in Saudi Arabia in 2012. Since then, it has been identified in many other countries, including the United States.
|Contagious (Disease), Respiratory|
The second subdivision of the Paleolithic, or Stone Age and consist of use of prepared cores (Levallois Technique) and hafted tools and weapons. ~300 kya -30 kya.
A period of geological time (781-126,000 years ago). An important time for the diversification of hominins, including the emergence of Neanderthals and Homo sapiens.
The element of an individual that enables them to be aware of the world and their experiences, to think, and to feel; the faculty of consciousness and thought.
|Mind Over Reality Transition (MORT)||
A proposed singular phase in hominid evolution in which maladaptive mortality salience and death anxiety were triggered by acquiring the capacity for Extended Theory of Mind, but were (in this one instance) tolerated by the simultaneous acquisition of Reality Denial in the same minds - allowing gene culture-evolution to fix both capacities in the resulting hominin lineage, at the neurobiological and genetic level.
|Mortality Salience, Reality Denial, Theory of Mind (ToM)|
The state of being conscious or aware.
A meditative practice centered around being present in the moment.
Fossils or fossil fragments of bacteria, protists, fungi, animals, and plants (e.g.: starch granules) that can only be seen with a microscope.
Short non-coding regulatory microRNA
Maternally inherited DNA found only in the mitochondria, the energy producing organelles of eukaryotic cells. Mitochondria are thought to descend from symbiotic bacteria that have become part of eukaryotic cells.
|Bacteria, Chromosomes, DNA, Eukaryotes|
The phenomenon whereby one organism produces molecules that are identical or very similar to those of another organism (such as its host). Parasites and pathogens repeatedly evolve molecular mimicry for host manipulation and immune evasion.
|Host, Parasite, Pathogen|
The rate of disease in a population (as opposed to mortality, which is death rate).
Shape or form (outward appearance) of an organism. The branch of biology interested in the form and structure of organisms and their specific structural features.
The sub-discipline of linguistics concerned with the structure and parts of words (stems, root words, prefixes, and suffixes), how words are formed, and their relationship to other words in the same language. Parts of speech, intonation and stress, and contextual pronunciation and meaning are aspects of Morphology.
Conscious understanding and realization of personal mortality.
The part of the cerebral cortex in the brain where the nerve impulses originate that initiate voluntary muscular activity.
|Mousterian (Mode 3)||
A stone tool type characterized by hand- axes, scrapers, triangle points, and denticulates (a stone tool with edges of multiple notched shapes, or teeth) produced using a prepared core (i.e. Levallois Technique) and is most associated with Neanderthals. ~315 - 30 kya.
A slimy or gooey substance (hydrated bio-gel) produced by mucous membranes and glands for to lubricate or protect the body. The substance we refer to as “snot” or “boogers” are the mucus inside your nose that traps dirt and germs before they can enter further into your body and do you harm. Sneezing expels these invaders from your body but also propels them out towards other unsuspecting victims.
A group of genetic diseases that cause progressive weakness and loss of muscle mass.
An auditory form of art composed of pitch (melody and harmony), rhythm (tempo, meter, articulation), dynamics (loudness/softness), timbre and texture.
|Musicality (in humans)||
A natural, spontaneously developing sensitivity to, knowledge of, or talent for music based on and constrained by our biological and cognitive system, which is then culturally informed and reinforced.